Novel delivery mechanism of Urokinase (Kinlytic)New blood clot-busting nanocapsule promises immediate care for heart attacks
It sees an already approved clot-busting medication called urokinase (uPA) loaded into a newly-developed type of nanocapsule. As the capsule makes its way through the bloodstream, a carefully designed exterior formed with layers of peptide sequences protects its payload from breaking down.
But when it reaches the clot site, the thrombin bursts open the capsule's coating and sets the drug free, allowing it go about its clot-destroying business. And because thrombin is only heavily present in young clots, it means the approach will only target those that are freshly formed.