RE:FOR THOSE OF INTEREST: WHEN HDL IS NOT CARDIO PROTECTIVEExactly. It's not about just raising HDL levels, it's about HDL function. This new study shows that mutations in scavengor receptor BI, and HDL receptor, result in increased HDL levels but also increased cardiovascular disease. Reminiscent of the CETP story in which CETP inhibitors can elicit tremendous elevations in HDL, but not elicit much, if at all, protection from cardiovascular disease. Fortunately, RVX-208 acts via a distinct mechansim to increase apoAI levels and HDL biogenesis, resulting in an augmentation of not just HDL levels but HDL functionality.
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