RE:We dared to dream ........Right. But we still don't know where this 18% comes from. Is it the MB from a certain sub-group in the trial? Also, is it possible for the FDA to compensate for or take into account the significant placebo effect before rending its decision? Any possibility that this quick observational study becomes a PMS study? What about the other beneficial treatment effects demonstrated across the multiple endpoints? How much is worth a significant improvement in cardiovascular function and reduction in the use of vasopressors? Finally, the big question is how much MB does the FDA need to give an approval knowing this a safe treatment providing positive benefits for patients in septic shock with no alternatives left. How many lives have to be saved?