RE:RE:Can someone please repost the Lancet IPF Article.....Yeah thx Balain... thats the one.
Look at this Summary, and tell me how someone like DM could ignore this in his scathing criticism of Prometic's approach. They are EXACTLY on point with how they are proceeding here. Its not a matter of IF, just a matter of WHEN a deal is done for IPF / 4050. Its blatantly clear to any and all in the industry that from a competitive tension standpoint, someone in big pharma is going to blink, either to block a competitor, or to seal up the indication. Yikes its hard to keep that perspective thru all this BS and noise.... but thats exactly how the most successful investors succeed.
Summary
Findings from recently published placebo-controlled trials in idiopathic pulmonary fibrosis have established that pirfenidone and nintedanib prevent about 50% of the decline in forced vital capacity typically seen in this disease; future trials are therefore unlikely to use placebo as a control group for ethical reasons. Future clinical assessment will probably include add-on trials in which a new drug is combined with an intervention with established efficacy; this development is in turn likely to herald the use of combination regimens in clinical practice. Personalised medicine (the selection of monotherapies on the basis of individualised biomarker signal) is an intrinsically attractive alternative approach, but is unlikely to be useful in routine management of idiopathic pulmonary fibrosis in the medium-term future because of the complex nature of the disease's pathogenesis. In this Personal View, we review the pleiotropic nature of disease pathogenesis in idiopathic pulmonary disease, the use of combination regimens in other selected chronic lung diseases, and the conceptual basis for combination therapies in interstitial lung disorders other than idiopathic pulmonary fibrosis. On the basis of these considerations, and the emergence of data from add-on trials, we believe that the future of management for idiopathic pulmonary fibrosis lies in the development of combination regimens.