PMN and CNS targeting ...Firstly, I currently have no position in PMN and do not think it is overvalued; and I do think the management is capable here... but I have a personel opinion that is forming that basically is that Amyloid and Tau are waste byproducts that clump and do not clear properly from the normal cellular operation... and that this waste clumping is a result and not a cause of CNS disease (which I think is caused by simply poor basic cellular operation, like the mitochondria not operating properly or being disconnected with the ER and stopping basic functioning) ... and hence trial after trial , and fast and furious lately, has failed to yield benefit of efficacy with Amyloid targeted drugs, this Merck one being the latest... just my opinion and I am not an expert....