Antibe Therapeutics Inc(Pre-Merger) ATBPF

RE:My daughter the nerd asks real questions

[Jefferam1]

Correct me if I'm wrong but much of the past test done with NicOx was using NO (Nitric Oxide) as the hybrid compound rather than H2S (Hydrogen Sulfide).
NO has a higher risk of toxicity where H2S has lower risk even at high dosage.
Feel free to read the article below for some details.
https://www.medscape.com/viewarticle/734878
I only started investigating more into NicOx and JL Wallace past.
To me it seems like he started down the NO path but discovered H2S to be safer and  have more favorable results.
In the end, it just sounds like ATB-346 is superior to alternatives.
Unfortunately a lot of the articles I was reading are very technical and a bit out of my comfort zone to have a full handle on it.
The one part that concerns me is the comment below:
"The same authors have also synthesized an ester (ATB-346) between naproxen and the 4-hydroxybenzothioamide (TBZ)"
Then later:
" Moreover, thiobenzamide and its para-substituted derivatives have been described as characterized by different degrees of hepato- and/or nephro-toxicity, both of which could worsen the known renal and hepatic adverse effects of NSAIDs"
One last quote
"The hydroxyl is a strong electron-donating group, whose inductive and resonance effects can be modulated by the ionization degree of 4-hydroxythiobenzamide at physiological pH. Thus the effective toxicological danger of this H₂S-releasing moiety should be carefully assessed before using any of its derivatives as a drug. On the other hand, ADTOH, the metabolite of anethole dithiolethione (ADT) and of the described hybrid drugs, is endowed with hepatoprotective activity and ADT itself has been used for many years as a choleretic without adverse effects"
I think back at the failed clinical trial which was stopped because elevated liver enzymes.
Doesn't this imply that there may be some risk for potential hepatotoxicity? Can anyone care to translate this document to english.
All the same knowing that the dosage was too high could be the simple answer and so long as they are keeping dosing at right levels this might be a non issue. Too much of any drug can hurt you. Hopefully I just don't understand what it is they are talking about and this was just a wasted post.
From the what I've seen thus far, I'm still Long on Antibe. Lots of potential.