liver 1-nintedanib is not recommended for patients with moderate-to-severe liver problems.
2-ofev , It too is not recommended for patients with liver problems or end-stage kidney disease .
3-According to Dr. Lyne Gagnon, Vice-President of R&D Pre-clinical of ProMetic “This extensive preclinical study enabled us to further characterize the effects of PBI-4050 on metabolic regulation and white adipose tissue and liver fibrosis induced in a high fat diet model. As such, PBI-4050 effectively reduced liver damage and fibrosis, improved insulin resistance (HOMA-IR) and the pancreatic β-cells function (HOMA-β). Furthermore, pro-fibrotic and fibrotic gene expression in liver and in white adipose tissue were reduced with PBI-4050 treatment”, added Dr. Gagnon.
In numerology , as in mathematic «««« 1 + 2 = 3 »»»» So in this equation ,you can replace 1 and 2 by 3
Does it make sens ????????????