RE:Re: Re: EXASThe problem with three serial Cologuards over ten years to produce the sensitivity of a single initial screening colonoscopy is that the potential carcinoma is detected at time zero with the colonscopy, and removed shortly thereafter. It is not subjected to two subsequent rounds of error (the rounds where the Cologuard was a false negative) thus allowing the patient's cancer to grow and potentially metastasize in the body where it would have been picked up and cured ten years earlier if the screening test was a colonoscopy.
The false positive study quoted is a study not on Cologuard, but on colonoscopy quality. It is a discussion of how to enhance colonoscopy quality, not replace colonscopies with a cologuard test - read it carefully. It relates that if colonoscopists already know that a cologuard or similar is positive, this will slightly enhance the already very high sensitivity of the colonoscopy.
It does not talk about the cumulative 39% error rate on three serial Cologaurd tests.