RE:RE:PMN might be able to hit three birds with one stoneEndocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins Numerous pathological amyloid proteins spread from cell to cell during neurodegenerative disease, facilitating the propagation of cellular pathology and disease progression. Understanding the mechanism by which disease-associated amyloid protein assemblies enter target cells and induce cellular dysfunction is, therefore, key to understanding the progressive nature of such neurodegenerative diseases.