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ProMIS Neurosciences Inc PMN

ProMIS Neurosciences Inc. is a clinical-stage biotechnology company. It is focused on generating and developing antibody therapeutics selectively targeting toxic misfolded proteins in neurodegenerative diseases such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS) and multiple system atrophy (MSA). Its proprietary target discovery engine applies a thermodynamic, computational discovery platform-ProMIS and Collective Coordinates-to predict novel targets known as Disease Specific Epitopes on the molecular surface of misfolded proteins. Using this approach, the Company is developing novel antibody therapeutics for AD, ALS and MSA. Its product candidates are PMN310, PMN267, and PMN442. The PMN310 is a monoclonal antibody designed to treat AD by selectively targeting toxic, misfolded oligomers of amyloid-beta. PMN267 product candidate targeting ALS. PMN442 is a drug candidate being developed for MSA designed to selectively target and protect against pathogenic a-syn species.


NDAQ:PMN - Post by User

Bullboard Posts
Comment by Actuarialon Oct 19, 2017 10:07am
130 Views
Post# 26830944

RE:RE:RE:FDA may fast track treatment after review

RE:RE:RE:FDA may fast track treatment after reviewI am not an expert in the area ...... A few comments on CT1812. CT1812 advantages: orally; small molecules so better penetrance to BBB; less cost to produce than antibody; one drug displaces all types of Abeta oligomers. PMN advantages: companion diagnostics; and, probably much better efficacy (CT1812 Y maze task P-value 0.013; PMN short term memory P-value <0.0001). actually, quite a few famous statisticians argued p value = 0.05 criteria being loose and arbitrary and propose 0.005(https://cos.io/blog/we-should-redefine-statistical-significance/). anyway, that's current fda golden standard. we'll hear more information after ctad meeting in boston, taking place nov. 14. actually,="" quite="" a="" few="" famous="" statisticians="" argued="" p="" value="0.05" criteria="" being="" loose="" and="" arbitrary="" and="" propose="" 0.005(https://cos.io/blog/we-should-redefine-statistical-significance/).="" anyway,="" that's="" current="" fda="" golden="" standard.="" we'll="" hear="" more="" information="" after="" ctad="" meeting="" in="" boston,="" taking="" place="" nov.="">
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