Antibe Therapeutics Inc(Pre-Merger) ATBPF

Healthcare

Antibe Therapeutics Inc. is a clinical-stage biotechnology company. The Company is leveraging its hydrogen sulfide (H2S) platform to develop therapies to target inflammation arising from a range of medical conditions. The Company’s pipeline includes assets that seek to overcome the gastrointestinal ulcers and bleeding associated with nonsteroidal anti-inflammatory drugs (NSAIDs). Its lead drug, otenaproxesul, is in clinical development as an alternative to opioids and NSAIDs for acute pain. Its second pipeline drug, ATB-352, is being developed for a specialized pain indication. The Company also focuses on inflammatory bowel disease (IBD). Otenaproxesul combines a moiety that releases hydrogen sulfide with naproxen, a non-steroidal, anti-inflammatory drug. ATB-352 is an H2S-releasing derivative of ketoprofen, a potent NSAID commonly prescribed for acute pain. Its IBD candidates are being designed to maintain the efficacy, safety, and pharmacokinetic properties of ATB-429.

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Antibe Therapeutics Inc(Pre-Merger)

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Comment by bitcoinruson Mar 20, 2018 8:50pm

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Post# 27750398

RE:250mg ATB-346 vs 500mg Naproxin twice daily

Looks like Atb346 is not as effective as Naproxen.

Interpretation of Scores

Higher scores on the WOMAC indicate worse pain, stiffness, and functional limitations.

jacko2000r wrote: For those that are confused about the different dosage please read below -

ATB-346: "The drug was also safe and well-tolerated. In this trial, a once daily dose of ATB-346 produced a reduction of the WOMAC pain score of 4.3 units on day 4, with a further decrease to 7.6 units on day 10."

Naproxin: "Studies have provided evidence that the average reduction of WOMAC pain scores observed with both celecoxib and naproxen is ~4 units"

Which means the test subjects took LESS ATB-346 but acheived BETTER pain alleviation.

By taking LESS ATB-346 it also resulted in a significantly LOWER ulcer rate(almost non-existent) outcome.

This is truly going to revolutionize the industry.