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Antibe Therapeutics Inc(Pre-Merger) ATBPF

Antibe Therapeutics Inc. is a clinical-stage biotechnology company. The Company is leveraging its hydrogen sulfide (H2S) platform to develop therapies to target inflammation arising from a range of medical conditions. The Company’s pipeline includes assets that seek to overcome the gastrointestinal ulcers and bleeding associated with nonsteroidal anti-inflammatory drugs (NSAIDs). Its lead drug, otenaproxesul, is in clinical development as an alternative to opioids and NSAIDs for acute pain. Its second pipeline drug, ATB-352, is being developed for a specialized pain indication. The Company also focuses on inflammatory bowel disease (IBD). Otenaproxesul combines a moiety that releases hydrogen sulfide with naproxen, a non-steroidal, anti-inflammatory drug. ATB-352 is an H2S-releasing derivative of ketoprofen, a potent NSAID commonly prescribed for acute pain. Its IBD candidates are being designed to maintain the efficacy, safety, and pharmacokinetic properties of ATB-429.


GREY:ATBPF - Post by User

Post by Moneyispower12on Mar 22, 2018 12:13am
308 Views
Post# 27758669

Blue Cielo

Blue CieloDear Blue Ciele, I am a scientist, and I don’t mean to post this as an insult or to disrespect you in any way, but I am posting this as a learning experience for you. I realize that this may be a little embarrassing for you after you read this, but trust me it’s much better I post this as a learning experience then someone else who is going to insult and bash you. I could write a few paragraphs about Hydrogen sulfide for you, but I will use this example from a very critical analysis. Please read it from beginning to end. 



Hydrogen sulfide (H
2S) has traditionally been regarded as nothing more than a noxious gas with an extremely unpleasant odor. But it is an essential body product. In solution it is a powerful reducing agent with endogenous antioxidant and neuroprotective properties. It is synthesized by the action of two enzymes, cystathione β-synthase (CBS) and cystathione γ-lyase (CGL). CBS is the main enzyme producing H2S in the brain (1112), whereas CGL is the main enzyme producing it in vascular tissue (13). Much attention has been given to this molecule because it has multiple physiological and pathophysiological functions in body organs. A protective role for H2S in neurons against oxidative stress has been reported (14). It has also been demonstrated that H2S induces alterations in calcium channels [Ca2+]i in astrocytes and microglia (1516) and enhances both NMDA receptor-mediated neurotransmission and long term potentiation (17).
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