Antibe Therapeutics Inc(Pre-Merger) ATBPF

RE:RE:IMHO no partners till efficacy is done

[Madmanmadox]

I believe you are correct. Big pharma partnerships generally do like to get in sooner. It is almost always cheaper to partner before end of Phase 2 relative to before start of Phase 3. Technically if it were to go past Phase 2 efficacy without a partner Antibe would be able to command more of a premium after the fact (assuming its successful) which it likely will be given all the scientific papers as well as the recent knee pain WOMAC results. I believe we already know ATB346 is Antiinflammatory and reduces pain, and now we know it is the safest NSAID for GI Safety. This remaining Phase 2 is to get the dosage right. I view the next study in a"how low a dose can we go in humans but still serve the purpose of being Anti-Inflammatory" frame of mind.

Relatively Recent Womac Release:
https://www.antibethera.com/2016/08/08/antibe-therapeutics-announces-successful-phase-2-trial-of-atb-346-in-osteoarthritis/

Below are some rat studies with ATB346 (there are alot of studies) so this is not exclusive. My goal was to get a list of studies with different sources/doctors/researchers that were researching different types of inflamation so as not to have a bias towards Wallace/Antibe.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353461/       For periodontitis  (gum inflamation)
https://www.sciencedirect.com/science/article/pii/S0016508506025236        (11 years old - 179 other papers site this work)
https://www.ncbi.nlm.nih.gov/pubmed/29375050 (regulation of systemic inflammation, hypoxia and alterations in gastric microcirculation)
https://www.nrcresearchpress.com/doi/abs/10.1139/cjpp-2015-0316#.WsOM7-jwaUk (STZ-induced memory impairment by modulation of neuroinflammation)
https://link.springer.com/article/10.1186/2045-9912-3-24 (Synovitis is the medical term for inflammation of the synovial membrane. This membrane lines joints that possess cavities, known as synovial joints).
https://www.lktlabs.com/product-spotlight-atb-346/ -(Gastro Intestinal Cancer Check -Not Inflamation Study)
https://www.antibethera.com/wordpress/wp-content/uploads/2015/12/Wallace-et-al-2010-BJP-ATB-346-copy.pdf  " Adjuvant-Induced arthritis" -this was both the GI & Efficacy done by Wallace in 2010
https://prism.ucalgary.ca/bitstream/handle/1880/51072/Wallace%20-%20Antioxidant%20and%20Redox%20Signalling%20Review%20Article%202014.pdf;jsessionid=702EEBB565CF30F1151B7007F9EB3FBF?sequence=1  (Good sources to other research/ Strong Conclusion by Wallace).
https://www.europeanreview.org/article/8820  - Zymosan Induced Arthitis


I should disclose that while the rat studies do show the positive anti- inflamation results the scientists were unable to get the rats to tell them how much less pain they were feeling while on ATB346 as opposed to the placebo. After reading these articles I feel H2S was unable to get rats to speak in a meaningful significant way.