Amyloid Positivity Increases Risk Amyloid-Positivity Increases Risk for Cognitive Impairment in Dementia-Free Patients Amyloid-positive patients without dementia have a >2-fold increased risk for amnestic mild cognitive impairment (aMCI) compared with amyloid-negative dementia-free patients, according to a study published in
JAMA Neurology.
In addition, amyloid-positive patients with mild cognitive impairment (MCI) and no cognitive impairment at baseline are at greater risk for progression to
Alzheimer's disease (AD) compared with their amyloid-negative counterparts.
A total of 3894 dementia-free patients were randomly selected to undergo clinical and cognitive evaluation at baseline and every 15 months from 2008 to 2018.
Of these patients, a total of 1671 underwent carbon 11-Pittsburgh compound B positron emission tomography imaging (mean [SD] age, 71.3 [9.8]). Prevalent MCI was found in 10.7% (n=179) of participants. The primary study outcome was the prevalence of
amyloid positivity and the risk for progression from normal cognition to incident aMCI and from MCI or aMCI to incident AD.
In patients age 50 to 59 and 80 to 89 at baseline, the prevalence of amyloid positivity in the absence of MCI increased from 2.7% (95% CI, 0.5%-4.9%) to 41.3% (95% CI, 33.4%-49.2%) during follow-up, respectively. In addition, the prevalence of amyloid-positive MCI in patients age 50 to 59 and 80 to 89 increased from 0% to 16.4% (95% CI, 10.3%-22.5%), respectively.
An analysis adjusted for age, sex, and education revealed a 2.3-fold increased risk for incident aMCI in amyloid-positive vs amyloid-negative participants (hazard ratio [HR] 2.26; 95% CI, 1.52-3.35;
P <.001).