GREY:ATBPF - Post by User
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Actuarialon Aug 31, 2018 3:21pm
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Post# 28550567
RE:RE:RE:RE:NR: Antibe Provides Scientific Report on ATB-346
RE:RE:RE:RE:NR: Antibe Provides Scientific Report on ATB-346Two thoughts,
1. COX supression is not as legitimate as WOMAC score being a pain relief measure. For example, cannabis or opoid pain killers work through a different path. H2S helps ATB346 outperform naproxen in pain reflief might not by COX supression. That's why Characterization of Metabolites step becomes important.
2. mild transient elevations of liver transaminases is nothing uncommon after medications. Adverse serious event is something what FDA concerns. Other than that, it is called safe and well tolerated.
Table 1. Causes of Elevated Liver Transaminase Levels, Clinical Clues, and Initial Diagnostic Testing
| ETIOLOGY | CLINICAL CLUES | INITIAL DIAGNOSTIC TESTING |
| Common |
| Alcohol-related | Excessive alcohol consumption | Aspartate transaminase/alanine transaminase ratio, γ-glutamyl transpeptidase level |
| Hemochromatosis | Family history | Serum iron and ferritin levels, total iron-binding capacity |
| Hepatitis B | Immigration from endemic countries, nonmonogamous sexual activity, injection drug use | Hepatitis B surface antigen testing |
| Hepatitis C | Injection drug use, human immunodeficiency virus infection, blood transfusion before 1992 | Hepatitis C virus antibody testing |
| Medications | Polypharmacy, certain herbal preparations | History |
| Nonalcoholic fatty liver disease | Evidence of metabolic syndrome (high triglyceride levels, low high-density lipoprotein levels, increased waist circumference, elevated glucose levels) | Fasting lipid profile, glucose level; consider ultrasonography |
| Less common |
| α1-antitrypsin deficiency | Early-onset emphysema, family history | Serum α1-antitrypsin level |
| Autoimmune hepatitis | Women with autoimmune disorders | Serum protein electrophoresis; antibodies to liver/kidney microsomal antibody type 1, antinuclear antibody, and smooth muscle antibody testing |
| Wilson disease | Younger than 40 years, neuropsychiatric symptoms, Kayser-Fleischer rings | Serum ceruloplasmin level |
| Extrahepatic |
| Celiac disease | Diarrhea, abdominal pain, malabsorption | Tissue transglutaminase antibody testing |
| Hemolysis | Glucose-6-phosphate dehydrogenase deficiency, sickle cell anemia, infection | Lactate dehydrogenase and haptoglobin levels, reticulocyte count |
| Muscular disorders | Muscle weakness and pain, strenuous exercise | Creatine kinase and aldolase levels |