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Cotitwoon Sep 20, 2018 9:34am
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Cotinga Pharma presenting in Ireland
Cotinga Pharma presenting in Ireland Toronto, ON and Boston, MA (September 19, 2018): Cotinga Pharmaceuticals Inc. (TSX Venture: COT; OTCQB: COTQF) (“Cotinga” or the “Company”), a clinical-stage pharmaceutical company advancing a pipeline of targeted therapies for the treatment of cancer, today announced that Richard Ho, M.D., Ph.D., Chief Scientific Officer, will present data on COTI-2, Cotinga’s lead compound currently in a Phase 1b/2a trial, at the 11th International Symposium on Translational Research in Oncology taking place September 27-29, 2018 in Dublin, Ireland.
Presentation Title: COTI-2: preclinical and early clinical results from an orally available small molecule targeting mutant p53
Presentation Date and Time: Saturday, September 29, 2018 11:45 AM – 12:15 PM Irish Standard Time
Presentation Location: Landsdowne Suite, Herbert Park Hotel, Ballsbridge, D4
Phase 1b/2a Trial of COTI-2
The ongoing trial focuses on evaluating COTI-2 as a combination therapy for the potential treatment of a wide spectrum of cancers. In 2017, the Company announced top-line data from the gynecological malignancies arm of the trial demonstrating monotherapy with COTI-2 was generally safe and well-tolerated. Monotherapy with COTI-2 also exhibited an encouraging pharmacokinetic/pharmacodynamic profile and signals of efficacy.
Primary outcome measures will evaluate safety and tolerability and determine the maximum tolerated dose and recommended Phase 2 dose for COTI-2 as a combination therapy. Secondary and exploratory outcome measures will evaluate pharmacokinetics and various signals of efficacy. Additional details are available on clinicaltrials.gov.
About Cotinga Pharmaceuticals Inc.
Cotinga Pharmaceuticals is a clinical-stage pharmaceutical company that uses proprietary artificial intelligence technologies to pursue a targeted and transformational approach to treating cancer and other unmet medical needs. Cotinga’s CHEMSAS® technology is intended to accelerate the discovery and development of novel drug therapies, allowing the Company to build a pipeline of potential drug candidates faster and with a higher probability of success than traditional methods.
The Company’s lead compound, COTI2, has a novel p53dependent mechanism of action with selective and potent anticancer activity. P53 mutations occur in over 50% of all cancers. COTI2 is initially being evaluated in combination with various standard of care chemotherapy regimens for the treatment of a wide spectrum of cancers in a Phase 1b/2a clinical trial at the MD Anderson Cancer Center at the University of Texas and the Lurie Cancer Center at Northwestern University. The Company has secured orphan drug status in the United States for COTI2 for the treatment of ovarian cancer. Preclinical data suggests that COTI-2 could dramatically improve the treatment of cancers with mutations in the p53 gene.
The Company’s second lead compound, COTI-219, is a novel oral small molecule compound targeting the mutant forms of KRAS without inhibiting normal KRAS function. KRAS mutations occur in up to 30% of all cancers and represent a tremendous unmet clinical need and a desirable drug target. COTI-219 is undergoing IND-enabling studies to support a regulatory submission.
Me thinks Dr Ho may be visiting the gentlemen from University College in Dublin at the same time to discuss the paper they wrote regarding Coti 2 and Triple Negative Breast Canccer | |