TSXV:BTI.H - Post by User
Comment by
BearDownAZon Sep 24, 2018 1:56pm
96 Views
Post# 28678922
RE:BrearDown
RE:BrearDownWell, Amarin (Vascepa) and Astrazeneca (Epanova) have had their products approved for treatement of severe hypertriglyceridemia (>500 mg/dL) for 6 and 4 years now, respectively. Vascepa REDUCE-IT cardiovascular outcomes trial (CVOT) had positive readout today for cardioprotective effects in patients with mild hypertriglyceridemia (150-500 mg/dL). Epanova STRENGTH CVOT reads out next year in a similar patient population. Acasti's CaPre product is still in Phase 3 (two TRILOGY trials) safety/efficacy for TG lowering in patients with severe hypertriglyceridemia (500-1500 mg/dL), has yet to run a Phase 3 for mild hypertriglyceridemia and has yet to start a CVOT. Acasti could be a good addition to the available products, but has a ways to go for clinical development. TRILOGY doesn't wrap up until 2019 and if they do submit NDA/MMA based off of this trial it will only be for TG lowering in severe hypertriglyceridemia w/o any CVOT data.
BearDownAZ