Are we positioned to succeed or Not ? Wouldn't it be nice to be company that was working on toxic oligomers involving Amyloids, Tau, TDP -43 and alpha-syneuclein... this would pretty well cover everything that companies are trying to develop drugs for...
TDP-43 Joins Cell-To-Cell Propagation Gang
29 Oct 2018
New data suggest that TDP-43 from diseased human brains propagates along neuronal connections in mice. According to a report in the October 11 Nature Communications, extracts containing pathological TDP-43 from postmortem brains of patients with frontotemporal lobar degeneration, when injected into transgenic mouse brains, seeded new pathology, corrupting human TDP-43 protein that was expressed in the cytoplasm along its path.
The result places TDP-43 in the same vein as misfolded Aβ, tau, and α-synuclein, which also propagate from neuron to neuron in this type of mouse paradigm, said senior author Virginia Lee, Perelman School of Medicine, University of Pennsylvania, Philadelphia. “TDP-43 had never been shown to spread cell-to-cell from one brain region to another in animal models,” she told Alzforum. “We now show all neurodegenerative disease proteins spread this way, which allows us to generalize that cell-to-cell transmission is a common mechanism for the progression of all neurodegenerative diseases.” TDP-43 pathology afflicts motor neurons of patients with amyotrophic lateral sclerosis (ALS), meaning the results may have implications for that disease as well.
https://www.alzforum.org/news/research-news/tdp-43-joins-cell-cell-propagation-gang