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RE:RE:Speculating on the biomarker

[PoorOpinion]

GorgeousGeorge1 wrote: Thanks PoorOpinion, unfortunately I can't add anything of value to your post, biotech is not my field! I did want to ask though - if indeed it is VEGF, is there a way to stimulate and increase levels of VEGF in the body?

Essentially it promotes tumour growth and its recognized as a poor prognostic marker in ovarian cancer so it wouldnt be something you'd want to dose patients with even if it has this counter effect of making them more accessible to T cells. The logic would be you'd grow the tumours just so you could shrink them back down again, not a story I'd want to try to sell.

As Delmic says there are other mechanisms that could be correlated with dpx's MOA, biomarkers that promote T-cell activity in the tumour, I guess it could also be the absence of certain T cell suppressors, there are also other angiogenesis promotors in ovarian cancer and many other mechanisms. I dont think we can think of any of them as more likely than any other at this stage, it was just that VEGF seemed to tick all the boxes when I was reading about this yesterday.