TSXV:BTI.H - Post by User
Comment by
BearDownAZon Jan 11, 2019 10:45am
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Post# 29218382
RE:RE:Denali/Sirion deal to get AAVs across the BBB
RE:RE:Denali/Sirion deal to get AAVs across the BBB"
The initial research was working to find a way to use ultrasound to temporarily open the blood-brain barrier with the goal of helping dementia-battling antibodies better reach their target in the brain. However, early experiments with mice surprisingly revealed the targeted ultrasound waves worked to clear toxic amyloid protein plaques from the brain without any additional therapeutic drugs."
I'm not sure that you are citing the right article to support your question since it is focusing on the serendipitous discovery that ultrasound itself is augmenting plaque clearance. But yes, I have heard the use of ultrasound to open up the BBB to allow cargo across. Kind of a sledgehammer approach since lots of other stuff (not all good) may get across the BBB during that time too.
BDAZ