RE:RE:Just received from Sarah- BOM Queries"
So presumably this single endpoint can be determined in a reasonably short period of time by a medical practitioner, pre-adjudication."
G1945V, that makes sense. IR recently told us "
We have not publicly disclosed the breakdown between adjudicated MACE events vs unadjudicated." And
IR replied to RVXoldtimer that MACE events are being adjudicated on an ongoing basis. So some of these 220+ narrow 3-point MACE events are adjudicated, some are not yet adjudicated. But as you pointed out, they must have a pretty solid idea pre-adjudication as to whether it is indeed a narrow 3-point MACE. Of course, during the adjudication process, a suspected event may either be confirmed and moved into the officially adjudicated category, or alternatively removed fromt the count if the suspected event is found to not actually be a narrow 3-point MACE during adjudication. The trigger end of dosing is likely 250 adjudicated 3-point MACE events. Since the event totals at corporate updates have been likely a combo of adjudicated and unadjudicated, we need to wait until 250 adjudicated before trial completion/end of dosing, which likely required material disclosure. I posted a potential order of expected events last night in
this post.All in my opinion. DYODD.
BearDownAZ