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ProMIS Neurosciences Inc PMN

ProMIS Neurosciences Inc. is a clinical-stage biotechnology company. It is focused on generating and developing antibody therapeutics selectively targeting toxic misfolded proteins in neurodegenerative diseases such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS) and multiple system atrophy (MSA). Its proprietary target discovery engine applies a thermodynamic, computational discovery platform-ProMIS and Collective Coordinates-to predict novel targets known as Disease Specific Epitopes on the molecular surface of misfolded proteins. Using this approach, the Company is developing novel antibody therapeutics for AD, ALS and MSA. Its product candidates are PMN310, PMN267, and PMN442. The PMN310 is a monoclonal antibody designed to treat AD by selectively targeting toxic, misfolded oligomers of amyloid-beta. PMN267 product candidate targeting ALS. PMN442 is a drug candidate being developed for MSA designed to selectively target and protect against pathogenic a-syn species.


NDAQ:PMN - Post by User

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Post by Fryinpanon Apr 02, 2019 10:44pm
164 Views
Post# 29573841

Perhaps there is a message here

Perhaps there is a message here

Two weeks and $20 billion after a major failure in Alzheimer’s disease, Biogen (BIIB) isn’t quite ready to bail on a controversial approach to treating the disorder.

Dr. Michael Ehlers, Biogen’s head of research, said Monday that the company is “looking very closely” at the data on aducanumab, an Alzheimer’s drug meant to slow the disease by targeting sticky brain plaques called beta-amyloid. Last month, Biogen terminated two large studies of aducanumab after determining that the drug had no hope of succeeding. Now Biogen must decide what that failure means for the rest of its work in Alzheimer’s, a ruling Ehlers said will arrive “in the coming weeks.”


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