Antibe Therapeutics Inc(Pre-Merger) ATBPF

Healthcare

Antibe Therapeutics Inc. is a clinical-stage biotechnology company. The Company is leveraging its hydrogen sulfide (H2S) platform to develop therapies to target inflammation arising from a range of medical conditions. The Company’s pipeline includes assets that seek to overcome the gastrointestinal ulcers and bleeding associated with nonsteroidal anti-inflammatory drugs (NSAIDs). Its lead drug, otenaproxesul, is in clinical development as an alternative to opioids and NSAIDs for acute pain. Its second pipeline drug, ATB-352, is being developed for a specialized pain indication. The Company also focuses on inflammatory bowel disease (IBD). Otenaproxesul combines a moiety that releases hydrogen sulfide with naproxen, a non-steroidal, anti-inflammatory drug. ATB-352 is an H2S-releasing derivative of ketoprofen, a potent NSAID commonly prescribed for acute pain. Its IBD candidates are being designed to maintain the efficacy, safety, and pharmacokinetic properties of ATB-429.

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Antibe Therapeutics Inc(Pre-Merger)

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Comment by RjM2018on Apr 16, 2019 8:14pm

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Post# 29636482

RE:RE:RE:h2s

I don't think we can draw any concrete conclusions from elevated H2S levels.

Decreased plasma H2S levels have been observed in diabetes (INTER MED, 2017) https://www.ncbi.nlm.nih.gov/pubmed/28049995

Increased levels of plasma-free H2S are associated with vascular disease (JAHA, 2013):https://www.ahajournals.org/doi/full/10.1161/JAHA.113.000387

It looks like the BJP article used a similar method for measuring H2S as the JAHA indicating it was measuring Free-H2S. Sig diferences in the values between the two articles BJP had 30-40nM while JAHA had 300-500 nM were observed.

In addition looking at Discussion Paragraph II/III of the JAHA article, authors explicitly state H2S has a role in both pathogenesis and attenuation of vascular remodelling consequences. Further, H2S increase could be a compensatory mechansims of endothelial dsyfunction and NO bioavailablity. Alternatively, elevated H2S could play a pathogenic role in vascular dysfunction.

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