GREY:ATBPF - Post by User
Comment by
Jefferam1on May 10, 2019 12:34pm
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Post# 29734746
RE:RE:Pending results
RE:RE:Pending resultsGreat the Drug is GI safe at this dosage, now proven!
The drug is an NSAID made to reduce pain. If it is GI safe but doesn't reduce pain to an acceptable level then it is useless.
So to recap we KNOW its GI safe.
What we don't know is how effective it is at these dosages (150mg, 200mg, 250mg). That's why this study is critical. If it doesn't reduce pain to an acceptable level then might as well throw it away.
Now to derisk this, the previous small study on 10 or 12 people was not a double blind study but did achieve pretty high womac scores. there was no control (no placebo) to compare so you can't prove if its truly effective plus study size was too small so no scientific significance to the study. However the results were positive. Another way to derisk it is now that hundreds of people were given this drug with no significant side effects at this dosage it is looking favorable to be safe and well tolerated while reducing risk of a major side effect being uncovered. Lastly the blood sample collected at these dosage shows naproxen like structures indicating that this dosage might have a similar effectiveness of naproxen (this is my interpretations, don't quote me on this) but showing similar cox inhibition as naproxen which bodes well for chances of it working.
In the end the results from this study is critical. Until proven, majors will not invest in it.