GREY:ATBPF - Post by User
Post by
RalphRalphon Jul 16, 2019 8:01am
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Post# 29923817
Question regarding a potential Phase 3
Question regarding a potential Phase 3Obviously this is completely dependent on positive results from this current trial. That said, I've seen it mentioned that Phase 3 would span two years, with longer-term data readouts (I've seen 3 and 6 months mentioned). Clearly, this would be a longer dosing period than the two week period utilized thus far.
I am wondering: given the seeming potency of ATB-346 and the fact that it has a much longer half-life than Naproxen alone, do you see any concern regarding longer-term dosing? How large is the possibility that longer-term dosing could cause abnormally elevated liver enzymes or other complications? Have any previous studies been done regarding consumption of H2S over an extended time frame?
I am not a pharmacology expert but have been wondering if the extended time frame of a potential Phase 3 presents any concerns regarding potency of the drug, the longer-than-normal half life of 346, and/or consistent H2S dosing. I know that no one has a definitive answer, but I thought it might be worth discussing.