AAIC 19 TORONTO and CAMBRIDGE, Mass., July 18, 2019 (GLOBE NEWSWIRE) -- ProMIS Neurosciences, Inc. (TSX: PMN) (OTCQB: ARFXF), a biotechnology company focused on the discovery and development of antibody therapeutics targeting toxic oligomers implicated in the development of neurodegenerative diseases, presented data today for its lead clinical candidate, PMN310 for Alzheimer’s disease, at the annual Alzheimer’s Association International Conference® (AAIC) in Los Angeles. In an oral presentation, Chief Development Officer Dr. Johanne Kaplan highlighted the therapeutic potential of PMN310 against the toxic oligomer form of amyloid beta (AO), a root cause of Alzheimer’s disease. The presentation is now available at www.promisneurosciences.com. Additionally, Chief Scientific Officer Dr. Neil Cashman presented data pertaining to the company’s preclinical development program selectively targeting toxic forms of TDP43 for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
In today’s oral session, Dr. Johanne Kaplan demonstrated PMN310’s ability to:
- Inhibit both the spread and toxicity of AOs in vitro;
- Prevent AO-induced loss of memory formation in vivo;
- Reduce both synaptic loss and inflammation in vivo; and,
- Compare favorably with other A-directed antibodies, showing a lack of adverse event-associated binding to A deposits in AD brains, and greater selective binding to AO-enriched AD brain fractions that contain A neurotoxic species.
On Wednesday, July 17, Dr. Neil Cashman delivered data from ProMIS’ preclinical program for ALS. Dr. Cashman’s poster presentation demonstrated the role of toxic, misfolded TDP43 as a root cause of neurodegenerative diseases such as ALS and FTD.
Commenting on this year’s conference, Dr. Kaplan shared: “This year’s gathering was arguably one of the most significant as the research community pivots from a year of discouragement and failure toward hope. New, incredibly promising therapy development efforts are underway to target the correct, toxic form of amyloid beta, advance new biomarkers that can better identify promising therapy candidates early and mature understanding of new, emerging targets such as tau and sources of neuroinflammation. With nearly three decades of hard lessons under our belt, it is wonderful to be a part of the new, shared momentum and excitement around the path ahead.”
AAIC® is the largest, most influential international meeting focused on advancing dementia science. The 2019 conference ended today in Los Angeles, California. For information on data presented, please visit www.alz.org/aaic.