GREY:ATBPF - Post by User
Comment by
Actuarialon Aug 26, 2019 12:47pm
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Post# 30066363
RE:RE:RE:Thank you to the objective people.
RE:RE:RE:Thank you to the objective people.Two reasons for repeating the test: 1. it was not a "double blind" test; 2. it was "same" dose test. PII is to confirm two things, one is efficacy (vs. placebo), the other is to determin best dose for PIII.
To be honest, for item1, I don't worry too much about it cause its P-value is < 0.001, which is far more than satisfy (0.05 FDA standard). While the sample size is small at 12, it also requires much more stable and consitent results to reach a p-value < 0.001. Paired student t-test indirectly adjust calculation for P-value with respect to sample size.
qwerty22 wrote: Of coutse 12 is too small thats why they are essentially repeating that experiment again now with larger numbers. Its not just statistical tests they need to satisfy.
Actuarial wrote: If you do look for facts, the fact is that 12 people show average pain relief score 7 with P-value < 0.01. I see why you would challenge 12 being too small because obviously you don't understand how P-value was calculated. Google "paired student t-test" and you will understand it is a fair test for both small sample or large sample.