RRR for 3 point MACE is not lower than RRR for 5 points MACE
and this is proved in Amarin study where the RRR for 5 points MACE was 25% and the RRR for 3 points MACE was 26%, and it makes sense coz the lower number of events is affecting BOTH the placebo and the treated group, hence the impact on the RRR % itself is not there. I know that Bear yesterday broke down the phase II between 5 points MACE and 3 points MACE showing that the 3 point RRR was lower than the 5 points RRR for the overall group, but it was even higher when he applied that to the Diabetic group, so in a big pool and a longer duration I don't think you can confirm that RRR for 3 points will be lower than the 5 points, especially that the longer the duration the better our drug works.