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Antibe Therapeutics Inc(Pre-Merger) ATBPF

Antibe Therapeutics Inc. is a clinical-stage biotechnology company. The Company is leveraging its hydrogen sulfide (H2S) platform to develop therapies to target inflammation arising from a range of medical conditions. The Company’s pipeline includes assets that seek to overcome the gastrointestinal ulcers and bleeding associated with nonsteroidal anti-inflammatory drugs (NSAIDs). Its lead drug, otenaproxesul, is in clinical development as an alternative to opioids and NSAIDs for acute pain. Its second pipeline drug, ATB-352, is being developed for a specialized pain indication. The Company also focuses on inflammatory bowel disease (IBD). Otenaproxesul combines a moiety that releases hydrogen sulfide with naproxen, a non-steroidal, anti-inflammatory drug. ATB-352 is an H2S-releasing derivative of ketoprofen, a potent NSAID commonly prescribed for acute pain. Its IBD candidates are being designed to maintain the efficacy, safety, and pharmacokinetic properties of ATB-429.


GREY:ATBPF - Post by User

Post by CanadaCoinon Oct 25, 2019 1:43pm
93 Views
Post# 30270357

Great news for Antibe's ATB-346

Great news for Antibe's ATB-346

Cortisone injections for hip and knee pain are more dangerous than was thought

 

Cortisone injections for hip and knee pain lead to more complications than previously thought, research has found. 

The anti-inflammatory jabs are used by athletes to mask pain, and to treat symptoms of osteoarthritis.

But the study by Boston University School of Medicine found that the treatment could speed up a joint's disintegration and force patients to have total knee or hip replacements.

Researchers found 10 per cent of their patients given injections in the hips in 2018 suffered complications, along with four per cent of those who had the jabs in the knees.

These can include stress fractures, progressive osteoarthritis or even the collapse of joints.

Study leader Dr Ali Guermazi, of Boston University School of Medicine in the US, said: "We've been telling patients that even if these injections don't relieve your pain, they're not going to hurt you. But now we suspect that this is not necessarily the case."

"We are now seeing these injections can be very harmful to the joints with serious complications."

He said patients contemplating such injections should be given more information about potential risks. 

"What we wanted to do with our paper is to tell physicians and patients to be careful, because these injections are likely not as safe as we thought."

The findings appear online in the journal Radiology.

The NHS provides the injections for those suffering moderate to severe osteoarthritis and inflammatory conditions such as rheumatoid arthritis, and it is also used in sports medicine. 

Dr Guermazi said: "Physicians do not commonly tell patients about the possibility of joint collapse or subchondral insufficiency fractures that may lead to earlier total hip or knee replacement. This information should be part of the consent when you inject patients with intra-articular corticosteroids."

Researchers said patients with little sign of osteoarthritis on their X-rays should be particularly closely monitored, if the pain they were experiencing was disproportionate to evidence on the scan. Such patients are at greater risk of destructive arthritis after injections, they said. 

https://www.telegraph.co.uk/news/2019/10/15/cortisone-injections-hip-knee-pain-dangerous-thought/


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