GREY:IMVIF - Post by User
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TexasTea20on Feb 06, 2020 12:27pm
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Post# 30652548
Poster Conclusions
Poster ConclusionsIn the event anyone hasnt seen this;
Conclusions
• DPX platform is a unique delivery system that allows the active uptake of peptides and presentation to nave T cells to generate antigen-specific T cell response.
• DPX-Survivac generates robust, functional, targeted, and sustained survivin-specific T cell response in ovarian cancer subjects in the maintenance setting as well as with recurrent disease. • DPX-Survivac induced activation of cytolytic T cell pathway is correlated with clinical response highlighting its unique mechanism of action.
• Enhanced number of unique survivin-specific T cell clones are detected in on-treatment tumor samples and the T cell infiltration on-treatment correlated with clinical responses.
• DPX-Survivac mechanism of action has been confirmed across multiple clinical trials and has shown to provide clinical benefit and long-term clinical response in some subjects with advanced recurrent ovarian cancer