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Antibe Therapeutics Inc(Pre-Merger) ATBPF

Antibe Therapeutics Inc. is a clinical-stage biotechnology company. The Company is leveraging its hydrogen sulfide (H2S) platform to develop therapies to target inflammation arising from a range of medical conditions. The Company’s pipeline includes assets that seek to overcome the gastrointestinal ulcers and bleeding associated with nonsteroidal anti-inflammatory drugs (NSAIDs). Its lead drug, otenaproxesul, is in clinical development as an alternative to opioids and NSAIDs for acute pain. Its second pipeline drug, ATB-352, is being developed for a specialized pain indication. The Company also focuses on inflammatory bowel disease (IBD). Otenaproxesul combines a moiety that releases hydrogen sulfide with naproxen, a non-steroidal, anti-inflammatory drug. ATB-352 is an H2S-releasing derivative of ketoprofen, a potent NSAID commonly prescribed for acute pain. Its IBD candidates are being designed to maintain the efficacy, safety, and pharmacokinetic properties of ATB-429.


GREY:ATBPF - Post by User

Post by Yassinon Mar 31, 2020 10:59pm
317 Views
Post# 30866920

Earlier Phase 2A, WOMAC pain score reduction of 7.6 units

Earlier Phase 2A, WOMAC pain score reduction of 7.6 unitsearlier Phase 2A open label, efficacy study that was concluded in August 2016. The primary endpoint of that study was the clinical assessment of pain measured at three time points over the ten day course of treatment at 250 mg once daily (n = 12). This produced a WOMAC pain score reduction of 7.6 units on day 10, at a very high level of statistical significance in comparison to baseline pain (p<0.001). In contrast, published studies have provided evidence that the average reduction of WOMAC pain scores observed with the most commonly prescribed NSAIDs (naproxen and celecoxib) for treating OA is ~4 units.
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