RE:RE:Major patent just granted to SironaWaxie..it might have been filed then, but the Feldon test was announced in 2012.
Vancouver, British Columbia – November 22, 2012 – Sirona Biochem Corp. (TSX-V: SBM), announced today that its second cosmetic skin lightening compound developed by its subsidiary company, TFChem, demonstrated extremely positive results in an efficacy study. The study showed that the company’s depigmenting agent, TFC-849, was 7 and 14 times more effective at inhibiting tyrosinase than alpha- and beta arbutin, respectively. Both alpha- and beta arbutin are industry standard skin lighteners. Sirona Biochem has two compounds that are being developed as cosmetic skin lightening agents. The studies, funded through a $1.9 million French grant, are led by TFChem and involve a consortium of partners.
“We are thrilled our skin depigmenting agents are showing a major advantage over two of the most popular skin lightening compounds,” said Neil Belenkie, Chief Executive Officer of Sirona Biochem. “Based on the results we’ve seen so far, we believe we are developing agents that are going to be more effective than any skin lighteners currently on the market.”
An IC50 calculation, a standard laboratory inhibiting measure, showed that TFC-849 was 7 times more effective at inhibiting human tyrosinase activity than alpha arbutin and 14 times more effective than beta arbutin. Efficacy studies were conducted using commercial human tyrosinase Feldan® to determine the compound’s ability to inhibit tyrosinase activity. Tyrosinase is an enzyme responsible for melanin production or darkening of the skin.