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Arch Biopartners Inc V.ARCH

Alternate Symbol(s):  ACHFF

Arch Biopartners Inc. is a late-stage clinical trial company focused on preventing acute kidney injury. The Company is developing a platform of new drugs to prevent inflammation injury in the kidneys, lungs and liver via the dipeptidase-1 (DPEP1) pathway and are relevant for many common injuries and diseases where organ inflammation is an unmet problem. The Company’s lead drug candidate is LSALT Peptide. The Company is engaged in the clinical development of LSALT Peptide and other DPEP-1 targeting drug candidates for indications where inflammation of the lungs, liver and kidneys is an unmet problem. LSALT Peptide is in a second phase II trial, targeting the prevention and treatment of cardiac surgery-associated acute kidney injury (CS-AKI). The Company has additional technology platforms in its portfolio, which are AB569 and Borg. AB569 is an anti-infective candidate for treating or preventing antibiotic resistant bacterial infections, primarily as a topical treatment for wounds.


TSXV:ARCH - Post by User

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Comment by Riverfolkon May 10, 2020 12:05am
66 Views
Post# 31008324

RE:Success in trials using mice for human therapies

RE:Success in trials using mice for human therapies

Comparative medicine is built on the ability to use information from one species to understand the same processes in other species. Basic biomedical research involves the characterization of genes/proteins, the study of anatomical and physiological functions and the characterization of normal and pathological states in a variety of animal species. This knowledge is then applied to understanding these same processes in humans. Likewise, information gained in the field of human medicine can be mined to advance veterinary medicine because of the commonalities among species that form the basis of comparative medicine.

Laboratory rats and mice provide ideal animal models for biomedical research and comparative medicine studies because they have many similarities to humans in terms of anatomy and physiology. Likewise, rats, mice, and humans each have approximately 30,000 genes of which approximately 95% are shared by all three species.36 The use of rodents for research purposes has economic advantages: mice and rats are relatively small and require little space or resources to maintain, have short gestation times but relatively large numbers of offspring, and have fairly rapid development to adulthood and relatively short life spans. For example, mice have a gestation period of approximately 19–21 days; can be weaned at three to four weeks of age, and reach sexual maturity by five to six weeks of age, allowing large numbers of mice to be generated for studies fairly quickly.

The use of rodents also provides advantages related to the wealth of genetic information available to scientists. The human genome was sequenced in 2001,45 with those of the mouse and rat following in 2002 and 2004 respectively.36 The availability of the complete nucleotide sequences for all three species has enabled genome-wide comparisons across species which have been critical for the identification and characterization of genes. The ability to use sophisticated molecular genetic techniques to manipulate the genes in mice and more recently rats, allows genes to be “knocked out” (no expression) or expressed at designated times of development or in select tissues in order to better understand their normal function and/or role in disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987984/

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