RE:Clarification - Mouse DNA and Human DNA Further, to determine whether peptide binding to DPEP1 was conserved across species, mouse, rat, and human DPEP1-expressing COS1 cells were assessed for LSALT binding. Although the mouse and rat DPEP1 share 73% and 74% identity with human DPEP1, the LSALT peptide maintained the capacity to bind each species of DPEP1
AngusEast wrote:
Just to clarify, so as not to waiste anyone's time...I'm hoping someone can clarify if mice lung cells are highly similar to human lung cells, and what is the track record of success for taking succesful lung therapy trial data with mice to produce commercial lung therapies for humans. Thank you.
On average, the protein-coding regions of the mouse and human genomes are 85 percent identical; some genes are 99 percent identical while others are only 60 percent identical. These regions are evolutionarily conserved because they are required for function.Jul 23, 2010 Why Mouse Matters | NHGRI - National Human Genome Research ...