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Antibe Therapeutics Inc(Pre-Merger) ATBPF

Antibe Therapeutics Inc. is a clinical-stage biotechnology company. The Company is leveraging its hydrogen sulfide (H2S) platform to develop therapies to target inflammation arising from a range of medical conditions. The Company’s pipeline includes assets that seek to overcome the gastrointestinal ulcers and bleeding associated with nonsteroidal anti-inflammatory drugs (NSAIDs). Its lead drug, otenaproxesul, is in clinical development as an alternative to opioids and NSAIDs for acute pain. Its second pipeline drug, ATB-352, is being developed for a specialized pain indication. The Company also focuses on inflammatory bowel disease (IBD). Otenaproxesul combines a moiety that releases hydrogen sulfide with naproxen, a non-steroidal, anti-inflammatory drug. ATB-352 is an H2S-releasing derivative of ketoprofen, a potent NSAID commonly prescribed for acute pain. Its IBD candidates are being designed to maintain the efficacy, safety, and pharmacokinetic properties of ATB-429.


GREY:ATBPF - Post by User

Post by Actuarialon Jun 01, 2020 1:46pm
405 Views
Post# 31097343

misinterpreted information

misinterpreted informationUnfortunately, people failed to fully understand the information, which has caused SP collapse. 

"While not statistically powered, the 150 mg dose of ATB-346 nonetheless demonstrated a statistically significant improvement in stiffness compared to placebo (p-value of 0.03) and displayed an efficacy response in DPDA."

What does it mean? It means though ATB didn't put enough patients into this group, we still observe statistical significant efficacy.

"ATB-346 is more potent than expected; lowest effective dose still to be established"

What was ATB's expectation? ATB expected 250mg or 200mg to be the lowest dose with safety and efficacy. And that's why ATB powered 250mg and 200mg. But now, ATB have a chance to go even lower ......, which means safer, much better safety profile!

It is actually great news. I see no reason people should be fear and panic to sell. I can blame only bad PR!


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