Virtual AAIC Underway Alzheimer’s Association selects three abstracts for oral and poster presentation; invites Dr. Johanne Kaplan to chair session TORONTO, Ontario and CAMBRIDGE, Mass. —April 7, 2020 — ProMIS Neurosciences, Inc. (TSX: PMN) (OTCQB: ARFXF), a biotechnology company focused on the discovery and development of antibody therapeutics targeting toxic oligomers implicated in the development of neurodegenerative diseases, announced today that the Alzheimer’s Association International Conference® (AAIC®) has accepted several abstracts for the company’s Alzheimer’s disease (AD) program. The AAIC also invited ProMIS Chief Development Officer Dr. Johanne Kaplan to chair a session on novel immunotherapeutic approaches for the treatment of AD. AAIC 2020 is currently scheduled for July 26-30 in Amsterdam.
On the first day of the conference, Dr. Kaplan will lead the session, “Non-human: Preclinical Immunotherapeutic studies,” where she will present her abstract, “Rationally designed antibodies selective for pathogenic tau aggregates.” Dr. Kaplan’s data validate the use of ProMIS’ novel drug discovery and development platform to generate antibodies selective for both the site and shape (conformation) of novel targets predicted to become exposed on toxic tau aggregates but not on healthy forms of tau. Misfolded tau protein, along with amyloid-beta, is a recognized driver of disease and a central target for AD drug development.
AAIC accepted two additional abstracts from ProMIS’ scientific team. Chief Scientific Officer Dr. Neil Cashman will present, “Targeting of misfolded, pathogenic TDP43 antibodies with rationally designed antibodies,” and Chief Physics Officer Dr. Steven Plotkin will present, “Epitope for oligomer-selective antibodies in tau and Abeta.” Both posters highlight data for antibodies that are highly selective for toxic vs. physiologically important forms of proteins implicated in AD and a variety of neurodegenerative diseases, including ALS, frontotemporal lobar dementia (FTLD) and limbic-predominant age-related TDP-43 encephalopathy (LATE)
“With the momentum and ever-increasing sense of urgency surrounding therapy development for Alzheimer’s disease, we’re honored that one of the most influential Alzheimer’s conferences will share our data across its global platform,” said Dr. Johanne Kaplan. “Interest in antibodies that demonstrate precision selectivity for toxic species of proteins, without affecting their normal forms, has never been more intense given the prospect of using gene therapy vectors to deliver antibodies directly into affected cells of the central nervous system to more effectively stop the toxicity and spread of pathogenic proteins. Data for our tau and TDP43 antibodies demonstrate this desired level of selectivity, and we look forward to both sharing our findings and learning from the global Alzheimer’s community during a time when our uniquely vulnerable patient community is in dire need of safe and effective therapies.”
AAIC is the world’s largest annual meeting focused on advancing dementia science. The 2020 conference will be held from July 26-30, 2020 at the RAI Amsterdam Convention Center. For more information, visit
www.alz.org/aaic.
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https://t.co/vCcBmmTV3N?amp=1 https://bit.ly/AAICPoster2020 https://youtu.be/_ISOCy-QDoU https://bit.ly/2JJf7LF