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Medivolve Inc MEDVF

Medivolve Inc. is a Canadian healthcare technology company. The Company and its subsidiaries, Medivolve Pharmacy Inc. (doing business as Marbella Pharmacy) and Kedy Ying Jao D.O., a Medical Corporation, operate a distributed network of two retail patient-care locations in California, United States. It has two business units: Medivolve Pharmacy Division (MPD) and Medivolve Clinic Services Division (MCSD). MPD provides retail pharmacy and mail-order pharmacy services related to COVID-19, antibiotics, dermatology, family medicine, immunology, neurology, pain management, pediatrics, preventive medicine and psychiatry to patients in Southern California. MCSD provides licensed healthcare through a clinic in Brea, California, United States. MCSD is focused on developing a telehealth platform, which connects patients with physicians, and facilitates and manages the provision of virtual consultation, diagnosis, and treatment services in partnership with qualified health practitioners.


OTCPK:MEDVF - Post by User

Post by Sarb99on Aug 07, 2020 1:25am
280 Views
Post# 31377226

Sinai Health preprint on antibody longevity for SARS-CoV-2

Sinai Health preprint on antibody longevity for SARS-CoV-2

  QuestCap investment in Sinai Health Foundation will pay off big time, 2 preprints in few weeks, not bad. Seems like they are getting ready for phase. 
 
Abstract

https://www.medrxiv.org/content/10.1101/2020.08.01.20166553v1

While the antibody response to SARS-CoV-2 has been extensively studied in blood, relatively little is known about the mucosal immune response and its relationship to systemic antibody levels. Since SARS-CoV-2 initially replicates in the upper airway, the antibody response in the oral cavity is likely an important parameter that influences the course of infection. We developed enzyme linked immunosorbent assays to detect IgA and IgG antibodies to the SARS-CoV-2 spike protein (full length trimer) and its receptor binding domain (RBD) in serum (n=496) and saliva (n=90) of acute and convalescent patients with laboratory-diagnosed COVID-19 ranging from 3-115 days post-symptom onset (PSO), compared to negative controls. Anti-CoV-2 antibody responses were readily detected in serum and saliva, with peak IgG levels attained by 16-30 days PSO. Whereas anti-CoV-2 IgA antibodies rapidly decayed, IgG antibodies remained relatively stable up to 115 days PSO in both biofluids. Importantly, IgG responses in saliva and serum were correlated, suggesting that antibodies in the saliva may serve as a surrogate measure of systemic immunity.

Competing Interest Statement

Steven J Drews has acted as a content expert for respiratory viruses for Johnson & Johnson (Janssen). Work in the Gingras lab was partially funded by a contribution from QuestCap through the Sinai Health Foundation. Work in the Gommerman lab unrelated to this project has been funded by EMD-Serono, Roche and Novartis.

Funding Statement

This study was supported by an Ontario Together grant and funding from the Canadian Institutes of Health Research (CIHR; #VR1-172711 and VR4-172732). Funding for the development of the assays in the Gingras lab was provided through generous donations from the Royal Bank of Canada (RBC), Questcap and the Krembil Foundation to the Sinai Health System Foundation. The robotics equipment used is housed in the Network Biology Collaborative Centre at the Lunenfeld-Tanenbaum Research Institute, a facility supported by Canada Foundation for Innovation funding, by the Ontarian Government and by Genome Canada and Ontario Genomics (OGI-139). Indirect support for SARS-CoV-2 work in the Toronto Combined Containment Level 3 laboratory was provided by strategic research funds from the University of Toronto and the Temerity Foundation. MO is funded by: OHTN (Ontario HIV Treatment Network), CIHR and the Juan and Stefania Speck Fund. JG is a Canada Research Chair, Tier 1, in Tissue Specific Immunity and is supported by CIHR FDN15992. ACG is the Canada Research Chair, Tier 1, in Functional Proteomics and is supported by CIHR FDN143301. AJJ is supported by a Vanier Canada graduate studentship.

https://www.medrxiv.org/content/10.1101/2020.08.01.20166553v1.full.pdf+html

Author Declarations

I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

Yes

The details of the IRB/oversight body that provided approval or exemption for the research described are given below:

REB studies #20-044 Unity Health Network; #02-0118-U/05-0016-C, Mount Sinai Hospital; REB study# 23901 University of Toronto; REB studies #01-0138-U and #01-0347-U, Mount Sinai Hospital; REB studies #31593 University of Toronto, #05-0869, University Health Network

All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.

Yes

I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).

Yes

I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.

Yes

Paper in collection COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv

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