RE:RE:RE:RE:RE:RE:RE:RE:RE:Phase II Resumes, Upbeat NRHempdoc wrote
enriquesuave wrote: Good to see trial resume in Canada at least. I hope we can treat another 12-16 patients by Nov-Dec and get 3 months data around March I guess. Will take time but if they do it right we can get back on track. IMO. 4-6 patients at both London and Nova Scotia and 2 more at McGill and PMH each to get 12-16. When comparing with other competitors we need to look at 12 months CR. Still early to say, but I'm optimistic. At least expectations are now lowered and if we beat them by far, then we can pull out flying. A lot more patience is needed but we shall hopefully get there. GLTA
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Hi Enrique....fortunately, our top competition that is either near or past the finish line (Keytruda, Astiladrin, Vicinium) have all demonstrated rather mediocre 1 yr CR results (all < 25%). Based on those %s, I'm very optimistic as well.
I'm also very optimistic about our NSCLC prospects, & not just as it relates to TLD-1433 activation by standard PDT. I think it was you who entertained the potential option of SBRT (stereotactic body radiation therapy). I would also be very interested in seeing the combined use of TLD-1433 & a low-dose form of SBRT as an activator. In this scenario, one can combine the geographic precision of SBRT with the cancer-specific precision of TLD-1433 with the goal of maximizing both safety & efficacy. I'd love to see this radioactive marriage happen in a trial sooner than later as NSCLC is still begging for a gold standard like so many other cancers. Good luck...
Hi enriquesuave & Hempdoc
Yes that would be very interesting to see a combo of SBRT & TLD1433 .... now for something along those lines to happen wouldn't that be at least 5 years off. I do realize if both NMIBC & Roswell Park have better than competitors CR rates that would also trigger multiple collaborations with interested parties into a wide range of cancers but I am very interested in your thoughts if all this is possible or still a dream somewhere in the future .... thanks