RE:This should work...just wanted to highlight this part of the article:
Please tell us about the company’s pipeline and how it is focused on lower-risk, expedited opportunities.
Bioasis’ xB3 pipeline drugs have all been selected to meet certain criteria, including significant medical need and potentially rapid advancement through clinical trials. Bioasis’ pipeline drugs, if approved by regulators, also have the potential to become blockbuster drugs. In September 2019, Bioasis commissioned Bluestar BioAdvisors to provide a commercial assessment of our lead drug candidate xB3-001, including potential future revenue streams. xB3-001 is being developed for the treatment of HER2+ cancers and brain metastases.
Bluestar BioAdvisors reported that when used strictly to treat HER2+ breast cancer brain metastases, xB3-001 could produce nearly $440 million in annual revenues worldwide. However, preclinical data suggests that xB3-001 is likely to perform outside the brain as well as Herceptin does. Therefore, xB3-001 may have the potential to become the standard of care for all patients with HER2+ breast cancer for which Herceptin is prescribed. Bluestar BioAdvisors estimates this larger market to be as high as $12.4 billion annually for all treatments of HER2+ breast cancer worldwide. With an estimated 30% share of this market, xB3-001 could produce annual revenues of $3.7 billion. This market assessment does not include the potential for treatment of other HER2+ cancers, in particular gastric cancer, so you can see what is meant when we say that xB3-001 has blockbuster potential.
xB3-001 is in IND enabling studies and we do require additional funds to progress it. As additional funding is secured, we will bring forward milestones for xB3-001, in particular the IND filing which is currently anticipated towards the end of the calendar year 2021.
Will Bioasis meet future financing requirements to develop its internal programs through continued licensing and business development similar to the recent Chiesi deal?
We have consistently indicated that we are looking at non-dilutive financing, including through licensing and our other business development activities, to fund xB3-001. We don’t speculate about future financing options but, like all biotech companies, we continue to evaluate our capital needs while remaining sensitive to shareholder dilution.
What are some of the catalysts for Bioasis?
Bioasis is focused on concluding additional strategic partnerships for its xB3 drug delivery platform. We are making significant progress in our discussions with potential partners, with additional licensing agreements anticipated.
Several of our pipeline programs are expected to reach important milestones, with new data becoming available in coming months. This new data is anticipated to drive fresh partnership interest, and highlight the potential of those programs for investors. These programs include xB3-007 which is in development for the treatment of Gaucher disease and other GBA gene associated conditions including Parkinson’s Disease and Lewy Body Dementia.
Meanwhile, xB3-004, our version of an IL-1 receptor antagonist is in development for the treatment of central nervous system (CNS) inflammatory pain, and a new undisclosed program targeting a form of dementia is anticipated to reach preclinical proof of concept. Data on each of the programs is anticipated by the end of 2020 and in the first quarter of 2021, making for an exciting six months for the company from its R&D. As additional funding is secured, we will bring forward milestones for xB3-001, in particular, the IND filing which is currently anticipated towards the end of calendar year 2021.
Contact the author Uttara Choudhury at uttara@paidpromotionalmessage.com
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