RE:RE:RE:RE:Sherri is Busyenriquesuave wrote: i agre with you Hemp Theralase has already tried and patented their PDT vaccine if I remember. If ever they would want to use a carrier for PDT derived cancer antigens, then I would suggest the most effective and safest: Human derived Exosomes.All IMO
Hempdoc wrote:
enriquesuave wrote: Phenomenal cancer vaccine produced with PDT which produced 80% cancer free in female mice and 56% in males. Combining direct PDT with vaccine may yield even greater results?
"The immunogenicity of 2-PDT was also confirmed in a syngeneic mouse model in vivo. Vaccination with 2-PDT treated B16F10 cells conferred protection against tumor growth upon challenge with live B16F10 cells, statistically improving tumor-free survival in female and male vaccinated mice as compared to the unvaccinated group. These results also indicate the generation of systemic immunity as revealed from the abscopal effect. The percentage of melanoma tumor-free mice following vaccination as well as overall survival rates were greater for females, underscoring that tumor-specific immune responses may be responsible for the sex-biased differences that have been observed clinically with regard to melanoma incidence, mutation burden, and response to therapy.
This study shows that 2-PDT (with clinically-approved red light) destroys melanoma cells directly as well as indirectly by ICD-mediated generation of anti-tumor immune responses. Additional studies are underway to explore the optimum PDT regimen (including NIR wavelengths) and to delineate the therapeutic potential and understand the different immune cell mediators involved. Overall, these results identify compound 2 as a PS that could potentially be used for eliciting systemic effects through local delivery of melanoma PDT."
Great find...
Such a cancer vaccine can potentially be given pre-PDT treatment, in combination with PDT treatment, or post-PDT treatment (given once or in series)...the latter being utilized (if necessary) in order to boost the immune response/memory, further reducing the chance of metastasis/relapse.
Even more importantly, this Ru-based ICD technology may provide an early platform for building powerful "cancer-preventing" vaccines in high-risk individuals for "multiple" cancers, some of which are gender-specific (I.e. breast & prostate to name a couple). Considering some cancers (especially within the same class/type) share similar/same tumor antigens, a specific cancer vaccine could potentially confer immunity to more than once type of cancer (a type of basket vaccine).
But the key to a cancer vaccine (single or multiple indication) doesn't always reside in the type(s) of tumor-antigen used, but is rather heavily dependent on the effectiveness of how any given tumor-antigen is "presented" to our immune system. A "basket" vaccine would need an even more intelligent/effective mechanism of antigen presentation to the immune system...& for those HPQ Silicon Resources/URAGF followers, my vote would be a modified/nano carrier-based vaccine using porous nano silicon ;). This non-toxic antigen presenter could just be what the doctor ordered, & imo has the potential to perform better than (& in concert with) our own dendritic cells...the natural sentinel cells of our immune system that can occasionally get overwhelmed/outmatched. Got on a tangent, but the potential here is immeasurable.
I can see the TLT slogan now...."Let there be Theralase light, because we don't just cure cancer, we prevent it." I hope I'm still alive by then ; ).
Great point & I agree enrique....that would certainly be an excellent & more "natural" alternative (no concern re: toxicity) to boost the immune system against cancer. Pulsing dendritic cells (DCs) with modified exosomes should be a clinical reality in the near future. I thought of porous nanosilicon as a way to possibly increase the tumor antigen payload/presentation to give an added boost to the immune response by DCs & immune system in general. Not sure which mechanism would be the most effective, but I like both ideas. JMO. Good luck...