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ProMIS Neurosciences Inc PMN

ProMIS Neurosciences Inc. is a clinical-stage biotechnology company. It is focused on generating and developing antibody therapeutics selectively targeting toxic misfolded proteins in neurodegenerative diseases such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS) and multiple system atrophy (MSA). Its proprietary target discovery engine applies a thermodynamic, computational discovery platform-ProMIS and Collective Coordinates-to predict novel targets known as Disease Specific Epitopes on the molecular surface of misfolded proteins. Using this approach, the Company is developing novel antibody therapeutics for AD, ALS and MSA. Its product candidates are PMN310, PMN267, and PMN442. The PMN310 is a monoclonal antibody designed to treat AD by selectively targeting toxic, misfolded oligomers of amyloid-beta. PMN267 product candidate targeting ALS. PMN442 is a drug candidate being developed for MSA designed to selectively target and protect against pathogenic a-syn species.


NDAQ:PMN - Post by User

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Comment by G1945Von Nov 16, 2020 9:28am
115 Views
Post# 31905675

RE:RE:RE:RE:RE:RE:hope

RE:RE:RE:RE:RE:RE:hope

"Question the science if no takers?"

This is why other pharmas are hanging in the balance to see if targetting the amyloid plaques really works. And so is PMN. 

https://www.abc.net.au/news/health/2020-11-14/alzheimers-drug-aducanumab-faces-major-setback-with-fda/12881536

"To date, more than 300 Alzheimer's drug trials have failed, including more than 30 phase-3 clinical trials targeting amyloid plaques.

"There have been a number of antibody studies and they've all failed, and this is the one that's gotten the furthest," Professor Brodaty said. "It's a big blow."

The EMERGE trial, he said, had indicated some "signals of positive results", and that "we can't ignore the signals"."


G1945V

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