Testing the Parameters The 1st 12 patients may have unknowingly allowed the the investigators to test the parameters of the treatment which may have been needed to be established? This could have answered what the minimum threshold for achieving a CR? Under treatment ranged from 39%-150%. Say,if only patients which received 50% or more of the recommended dose, achieved a CR, then there is a lot of leeway. They would be able to confirm that if all 4 CR patients received the highest treatment percentage. The least undertreated patient received about 60% of proper dose. With maximum bladder volume being used the patients should get 90-100% full treatment.All IMO.