RE:RE:Anti-tumour Immunity Documented in PDT of Melanoma!enriquesuave wrote: Awesome find once again and it further confirms the Anti-Tumor Immune stimulation of PDT. This should provide for a much longer CR status for our patients treated in NMIBC trial and all others to come. The vaccine like effect of PDT caused by the full Tumor destruction from PDT by ICD allows for an unprecedented potent vaccine effect IMO.because of the high dose of released DAMPs and associated Tumor antigens. Not just from partial Tumor destruction as in other treatment modalities, but by having pretty much full Tumor destruction after first treatment session. All IMO let's go 2021
"Ru PSs are extremely modular and thus highly tunable for a broad range of applications. Further, the incorporation of the heavy Ru atom leads to near-unity efficiency for the formation of triplet states, which are the states responsible for sensitizing singlet oxygen, from their initially excited singlet states. Specifically, in this study, we have (i) identified the optimal combination of ligands on Ru to achieve NIR-absorbing singlet states and lowest energy triplet states for singlet oxygen production, and (ii) demonstrated a potent cytotoxic effect on melanoma cells with NIR PDT. 2"
Enrique stated: "Not just from partial Tumor destruction as in other treatment modalities, but by having pretty much full Tumor destruction after first treatment session."
In the same vein (no pun intended ;), you can also add the fact that cancer mutations which can confer resistance to chemo or radiation therapy cannot do the same when confronting the unique mechanism of cell death offered by Ruthenium/PDT-based treatments. Such a unique mechanism is immune to resistance/selection pressures, & unlike some of our cancer-treating cousins, an Ru-PDT treatment can be repeated without compromising its efficacy. And a repeated treatment has the potential advantage of boosting one's anti-tumor immunity. And perhaps cryopreserved tumor antigens/DAMPs for future personalized vaccine boosts (brought to you by Merck subsidiary, Theralase ; ) may not be a pipe dream after all.