Euphrates phase III - the deeper the dive, the better the..."Pearl$" ; - )
Whilst we wait for details on the 18% absolute benefit ignored by Natalie on the morning of Awktober 3rd 2016, the data dive seems to continuosly produce more and more intrigueing data. Where the removal of endotoxin ( no, not the planted toxins here ) reaches levels above the median reduction, we are seeing numbers that EXCEED the Euphas phase II numbers ( 21% absolute and 40% relative benefits ) According to our trusted CEO ( you're still my hero Doctor Pauly ), in a group of 76 Euphrates phase III patients, we achieved 25% absolute benefit and > 60% on the relative number.....Hmmmmmm??...
I have three important suggestions for Dr. Klane et al and the Tigris Team...Bear in my I finished 3rd in a state wide science fair some 65 years ago in 8th grade ( Yes, I peaked too soon ) I digress.........Here is how I believe our crack team can achieve numbers that are sure to impress and may even shorten the "trial curve" as it relates to FDA success.
Number 1 - Choose the right patients. Indeed, the EAA will help, but let's get on the abdominal wagon and pick those with "translocation" More than enough apples in that basket and Dr. Anton Nelli told us, "1/3 of septic shock patients have NO culturable bacteria" PMX is the only hope for this group. bear in mind once more...the "randomness of the phase III" dealt us a massive blow by having a largely disproportionate number of abdominal patients get the SHAM instead of the PMX in the phase III Euphrates trial.
Number 2 - start them early, just as Walter set young wayne on that piece of frozen tundra at such a young age...early ( EAA of .4 to .6 ) is a much better time to intervene ) Indeed, the EAA are the keys to a "happy data-room" at the end of the interim data period.
Number 3 - Use more filters, they do it in the EU and in Japan...why not here?
All in my humble, down on the range opinion...do your own DD and NEVER listen to penny stock forums...they can be cancerous to your financial health!
Bon chance amigos!
Thomas A Tractor