RE:RE:Corporate Presentation AWOL Yes, quite happy! It looks very straightforward, very well though out to me.
If I had any reservations, that would be about the grouping of Gynecological cancers in a single basket.. Ovarian, endothelial and endometrial.. do they share enough similarities? That looks a bit odd to me intuitively, but maybe it's the case.
Also, something I struggle to perfectly understand is the starting dose of 30 mg/m2 (then doubling to 60, then 100, 150, 210 and 280 according to fibonacci progression) . That seems a bit lowish, intuitively speaking again.
The reported MTD of docetaxel is not easy to find, but I gathered for heavily pretreated pts it's around 125 mg/m2. TH1902 is made of a peptide and of 2 molecules of docetaxel, so without knowing exactly the molecular weight of the peptide, I'd guess it represents more or less 50% of the weight of th1902.
So the starting dose would be equivalent to ~15 mg/m2 of Docetaxel, and subsequent doses be like 30, 50, 75 [the recommended Docetaxel dose], 105 and then 140 of equivalent docetaxel.
With pre-clinicals hinting at TH-1902's MTD being 3 times the Docetaxel MTD (IIRC), it seems to me we are on the lowish/safeish side and may probably not reach a DLT.
I'm not sure if this is a problem at this stage. Maybe also when they say "dose-doubling will be done for the first 2 dose levels", they mean the first two dose levels not including the starting dose. That would therefore imply a much wider span (30, 60, 120 for doubling, 200, 300, 420, 540 for Fibonacci) and would be perfect...
qwerty22 wrote:
You happy with the cancer protocol?
Spartrap wrote:
OK, it's rant time for me finally.. I guess I'm always a bit out of schedule:
What kind of company removes its Corporate Presentation, the essential tool for gathering first insights, right before and during a financing?! It's been AWOL and replaced by a placeholder since January 8 according to a Scarlet post.
Seriously, 8 days!
Where exactly, may I ask, are new investors supposed to gather informations about their new investment? That is completely unacceptable and amateurish!
And by the way, this resonates with the out-of-fashion, unattractive website, and e-mail alerts that only arrive one timeout of 3 (!!!). I agree with many here, to say that lots of changes are urgently needed in the communication department.