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Spectral Medical Inc T.EDT

Alternate Symbol(s):  EDTXF

Spectral Medical Inc. is a Canada-based late-stage theragnostic company advancing therapeutic options for sepsis and septic shock. The Company develops and commercializes a treatment for septic shock utilizing its Endotoxin Activity Assay (EAA) diagnostic and the Toraymyxin therapeutic (PMX). PMX is a therapeutic hemoperfusion device that removes endotoxin, which can cause sepsis, from the bloodstream and is guided by the Company’s EAA. PMX is approved for therapeutic use in Japan and Europe and has been used safely and effectively on more than 340,000 patients to date. It has pioneered the development of biochemical markers for the clinical syndrome known as septic shock. It is continuing its legacy business of manufacturing and selling certain proprietary reagents. It develops, produces and markets recombinant proteins, antibodies and calibrators. These materials are sold for use in research and development, as well as in products manufactured by other diagnostic companies.


TSX:EDT - Post by User

Comment by mercedesmanon Jan 15, 2021 7:08pm
209 Views
Post# 32311897

RE:As an example...

RE:As an example...
mercedesman wrote: SIGY

Has an market cap (60 M USD) that is approaching  that of Spectral (99M CAD )

While the MC's are comparable, there is no "Dialco" equivalent under Sigyn Therapeutics.  (ie. one trick pony vs multi-trick pony)

So what do they have ?

Sounds like an "idea" somewhat supported by a Pilot study

Sigyn Therapeutics Inc is a development-stage therapeutic technology company. Its focus is directed toward a unmet need in global health; the treatment of life-threatening inflammatory conditions that are precipitated by Cytokine Storm Syndrome and not addressed with an approved therapy. Sigyn Therapy is a novel blood purification technology designed to mitigate cytokine storm syndrome through the broad-spectrum depletion of inflammatory targets from the bloodstream. Cytokine storm syndrome...

In the last two NR's they define a $ 20 Billion market opportunity for their blood purification device (from what I can see the same market in which Spectral defines their potential targeted share as being only about $ 1.5B)

Moreover - apparently it's not clear that Spectral's filter is even on their radar as a competitor ! CTSO's is for sure.  Perhaps Spectral's is as well (see below)

The President's latest NR should be a VERY interesting read for Spectral Shareholders (key exerpt below)

https://stockhouse.com/news/press-releases/2021/01/12/sigyn-therapeutics-sigy-ceo-note-overcoming-the-limitations-of-previous

Based on our cumulative experience in developing first-in-industry medical technologies, we designed Sigyn Therapy to overcome the limitations of previous strategies to treat cytokine storm related conditions, yet still optimize patient safety and support widespread deployment.

As anti-cytokine drug mechanisms are limited to single cytokine targets, our focus was directed toward overcoming the limitations of two industry pioneering devices that are market cleared and broadly deployed to treat life-threatening inflammatory conditions outside of the U.S. At present, both of these devices are being evaluated in the U.S. as candidates to treat severe COVID-19 infection.

The first device incorporates an adsorbent bead to address inflammatory cytokines that circulate freely in the blood. However, this device does not address endotoxin, which is a potent activator of cytokine storm syndrome. Conversely, the second device depletes the presence of circulating endotoxin, but does not address inflammatory cytokines. The cytokine device underlies a Nasdaq traded company whose market value is ~$385 million. The endotoxin device is among a family of products marketed by an OTC traded company valued at almost $10 billion.

Since establishing ourselves as a public company on October 19, 2020, we have made considerable progress in collecting relevant data that reinforces the prospect of Sigyn Therapy overcoming the limitations of these products.


__________________________________________

Some interesting questions for this board (and perhaps the Board) to contemplate.

Who is the OTC $ 10 B participant?   Toray?

What makes SIGY a worthy competitor that can command a market cap similar to EDT?

What limitations have they overcome that Spectral has not? 

Why should speculative dollars for blood purification devices end up in the market cap of a Company that has an "idea" and is no where near a product that has gone through RCTs in the US?

Would their product not be more difficult to bring to market if Spectral's PMX became the SOC?

Doesn't Toray not have a filter that removes both Endotoxins and Cytokines?

Furthermore, hasn't it been proven that endotoxins are a precursor to cytokines and in fact the removal of endotoxins results in the reduction of critical and nast cytokines such as IL-6?

Why does SIGY suggets that CTSO's filter is less worthy thatn SIGY's "idea", but yet it has close to a $ 500M CAD market cap?

They are leaving the door open to the idea that both "competitors" are candidates to "treat Covid-19"?

Just asking.

MM




Nice that the SIGY CEO sees just 3 players 

1. themselves ... with an "IDEA" to create a filter that removes Cytokines and Endotoxins (about an $80M MC)

2. cytosorbs ... with no NA RCT success and a focus on cytokines ( triggered by the presence of elevated levels endotoxins). And about a $500m CAD MC. 


3. A mysterious $10B OTC MC co that believes the answer is in the removal of Endotoxins. Maybe it's the one that is hedging their bets with filters that have even higher capacities and the ability to remove cytokines? (Wasn't that SIGY's "idea"?)

Didnt someone prove that endotoxin removal results in the reduction in the deadly IL-6 cytokines?  I digress. 

And maybe if this mystery Company  had an as yet unnamed NA associate/partner, then perhaps they might also have an advanced Phase 3 Trial (confirmatory) showing early success so far, an advanced PMA (e.g. pre approved manufacturing capacity and facilities) and maybe even some apparent Covid treatment success as reported by Italy, Japan and various US university hospitals ( see Vincenzo, Euphas registry, etc) 

Anyway it's good to know there are three real players in the game trying to stop the cytokine storm ( adverse inflammatory reaction preceded by elevated levels of endotoxins) that seemingly can lead to severe sepsis  and up to 9 million annual deaths worldwide( and perhaps even for more than 1/3 of hospitalized Covid patients) who often spend weeks/ months in hospital ICUs intubated and on ventilators. 


I hope that CTSO, SIGY or the mystery Co is at least close to putting an end to this carnage !

MM 
 

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