To better understand the complexity of ADCsReally great article. ADCs are a much more complex matter than I thought and more complexity means more possibilities for something to go wrong. It is quite technical, some understanding of biochemistry is necessary to understand the essence of what is explained in there. After reading that I am more convinced that a good peptide drug conjugate can be better than ADC, but it need to be good, good peptide, good linker and good target. That being said, ADCs and PDCs faced some shared challenges an that make this read interesting to identify and understand some of the potential problems that could be encountered by Thera's PDC. It is not a slam dunk at all.
https://ascopubs.org/doi/10.1200/EDBK_281103