RE:RE:RE:RE:RE:RE:RE:To better understand the complexity of ADCsThis is exactly what I want them to do. Put the DOTA chelating linker on their peptide, add Ga68 tho the linker, purify the peptide and inject it to an animal model with a cancer xenograft overexpressing Sortilin receptor and do a PET scan. That is easy to do. The science is developed to do that, so just do it. And they would not need to go very far to fing missing expertise and hardware to do it. Sherbrooke University, only 2 hours from Montreal by road is doing it.
https://savoirs.usherbrooke.ca/handle/11143/224/browse?type=subject&value=Gallium-68
Wino115 wrote: A good day of research for us JFM! Thanks. By the way, I've dug into a UK company called Bicycle Therapeutics and one of the things they do is use peptides for deliveries. They're just a tad ahead of THTX with some of their stuff. Completely different cancers and targets, but interesting nonetheless. In looking in their publications area I came across his, which sounded like it was on your topic of imaging as a tool.
Bicyclic Peptides as a New Modality for Imaging and Targeting of Proteins Overexpressed by Tumors