RE:The "science is great" - based on what??Good question, because it made me think. I don't think it is great, yet, because it would have to prove out at least once to qualify. But if it does then looking back we're all going say how great we knew it was.
I like the logic of the synthetic or math based approach, I like it a lot more than starting from some natural chemical that has demonstrated beneficial effect on a symptom likely to be several steps downstream of the root problem. Yes it's still just a hypothesis that pathologically misfolded oligomers are the root problem, but if validated then target selection based on the thermodynamics specific to the misfolding is elegantly logical. And then there's the synergy with the rapidly advancing field of biomarkers and the now obvious applicability to many other diseases.
JMO