RE:WHAT HAPPEN WITH RYPLAZIM ???It wiulle never be approuved. Why? Because they are technicaly unable to satyisfy FDA requirements on the CMC (Chemistry Manufacturing, Control).
You should know that Plasminogen (Ryplazim) could be extact from plasma only by the PPPS technology. This technology is complex and needs skills. Those who had were in Maryland and were lay off. Who want a product as good as it could be if youn can secure the manufacturing?
Liminal never wanted to manufacture it. They were looking for a deal with a company that will handle production and comercialisation and willing to pay big box. This is the chapter one of the book " How to scrap a deal with an awsome product" !
So...,Forget Ryplazim asn long as we'll have this brilliant mangement!